Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.64 |
| ▸ | PDE4A | P27815 | 18/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763968 | 1.00 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL7763150 | 0.98 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL7764127 | 0.98 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL7763127 | 0.98 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL8483296 | 0.87 | PDE4D (0.59) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6585249 | 0.86 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL11435807 | 0.86 | PDE4B (0.77) | PDE4BPDE4DPDE4APDE4CLMNA | |
| SCHEMBL7906256 | 0.82 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CCYP3A4 | |
| SCHEMBL8486187 | 0.81 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7174439 | 0.80 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | claimed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |