Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760278 | 0.90 | PDE4B (0.82) | PDE4BPDE4DKMT2ALMNAPDE4A | |
| SCHEMBL7763958 | 0.90 | PDE4B (0.82) | PDE4BPDE4DKMT2ALMNAPDE4A | |
| SCHEMBL7764115 | 0.90 | PDE4B (0.82) | PDE4BPDE4DKMT2ALMNAPDE4A | |
| SCHEMBL8486179 | 0.90 | PDE4B (0.67) | PDE4BPDE4DKDM4EMAOAKMT2A | |
| SCHEMBL7764403 | 0.87 | PDE4B (0.65) | PDE4BPDE4DKDM4EKMT2APTGER3 | |
| SCHEMBL7765557 | 0.87 | PDE4B (0.65) | PDE4BPDE4DKDM4EKMT2APTGER3 | |
| SCHEMBL7763217 | 0.87 | PDE4B (0.75) | PDE4BPDE4DKDM4EKMT2APTGER3 | |
| SCHEMBL7764133 | 0.87 | PDE4B (0.75) | PDE4BPDE4DKDM4EKMT2APTGER3 | |
| Daxalipram SCHEMBL450824 | 0.87 | PDE4B (1.00) | PDE4BPDE4DKDM4EKMT2ALMNA | |
| Daxalipram SCHEMBL450823 | 0.87 | PDE4B (1.00) | PDE4BPDE4DKDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186129-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-01-29 | — | — | US | claimed |
| US-4186129-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-01-29 | — | — | US | disclosed |