Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765809 | 0.78 | EHMT2 (0.42) | ALDH1A1SMN1; SMN2HTTL3MBTL1LMNA | |
| SCHEMBL7767452 | 0.76 | CRBN (0.43) | ALDH1A1SMN1; SMN2HTTL3MBTL1LMNA | |
| SCHEMBL19700851 | 0.68 | PTGER4 (0.39) | ALDH1A1HTTL3MBTL1KCNA5GAA | |
| SCHEMBL7766815 | 0.67 | CRBN (0.43) | ALDH1A1SMN1; SMN2HTTL3MBTL1LMNA | |
| SCHEMBL7764955 | 0.67 | EHMT2 (0.38) | ALDH1A1SMN1; SMN2HTTL3MBTL1LMNA | |
| SCHEMBL7766697 | 0.66 | EHMT2 (0.38) | ALDH1A1SMN1; SMN2HTTL3MBTL1LMNA | |
| SCHEMBL22728271 | 0.65 | KMT2A (0.51) | ALDH1A1SMN1; SMN2HTTL3MBTL1KMT2A | |
| SCHEMBL15042316 | 0.65 | KCNA5 (0.46) | ALDH1A1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL19700849 | 0.64 | KCNA5 (0.45) | ALDH1A1HTTLMNAKCNA5ALOX15 | |
| SCHEMBL9781790 | 0.64 | KCNA5 (0.45) | ALDH1A1KCNA5DHFRTSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639566-B1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5461158-A | Immunodeficiency and autoimmune diseases | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0639566-A1 | CYCLIC COMPOUND | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-02-22 | — | — | EP | disclosed |