SCHEMBL7765034

SCHEMBL7765034

CCCC[Si](C)(Cl)O[Si](C)(Cl)CCCC

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.32
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7765023 0.82
SCHEMBL18108311 0.81
SCHEMBL18108299 0.79
SCHEMBL7770157 0.74 TSHR (0.33) TSHRTDP1LMNATHRB
SCHEMBL27932615 0.74
SCHEMBL708796 0.73 TSHR (0.38) TSHRTDP1LMNATHRB
SCHEMBL446925 0.73
SCHEMBL18108039 0.72 LMNA (0.39) TSHRTDP1LMNATHRB
SCHEMBL18108126 0.72 LMNA (0.39) TSHRTDP1LMNATHRB
SCHEMBL11200 0.71 TSHR (0.35) TSHRLMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114901690-A Treatment of cancer with Antibody Drug Conjugates (ADCs) that bind 191P4D12 protein 艾更斯司股份有限公司 2022-08-12 CN disclosed
EP-1114824-B1 Process for preparing 1,3-dihalo-1,1,3,3-tetraorgano disilioxanes WACKER CHEMIE GMBH (DE) 2001-12-12 EP disclosed
US-6284907-B1 REACTING HYDROGEN HALIDE WITH THE CORRESPONDING 1,3-DIHYDRO-1,1,3,3-TETRA(ORGANYL)DISILOXANES; CATALYST SELECTED FROM TRANSITION METALS OF THE 8TH SUBGROUP OF THE PERIODIC TABLE OF THE ELEMENTS, OR COMPOUNDS OR COMPLEXES WACKER-CHEMIE GMBH (DE) 2001-09-04 US disclosed
EP-1114824-A1 Process for preparing 1,3-dihalo-1,1,3,3-tetraorgano disilioxanes Wacker-Chemie GmbH (DE) 2001-07-11 EP disclosed