SCHEMBL7765299

SCHEMBL7765299

CCCCC[SiH]1CCC([C@H]2CC[C@H](CCCCc3ccc(OCC)c(F)c3)CC2)CC1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.34
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33
S1PR3 Q99500 3/20 0.32
S1PR1 P21453 3/20 0.32
ACE2 Q9BYF1 1/20 0.32
S1PR2 O95136 1/20 0.32
LPAR2 Q9HBW0 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2C8 P10632 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7765303 1.00 KDM1A (0.34) KDM1AITGB3ITGA2BS1PR3S1PR1
SCHEMBL7765309 1.00 KDM1A (0.34) KDM1AITGB3ITGA2BS1PR3S1PR1
SCHEMBL7767968 0.92 S1PR1 (0.34) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7765298 0.92 HTR2A (0.32) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7765307 0.92 HTR2A (0.32) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7769731 0.92 S1PR1 (0.34) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7767971 0.92 S1PR1 (0.34) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7769725 0.92 S1PR1 (0.34) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7765302 0.92 HTR2A (0.32) ITGB3ITGA2BS1PR3S1PR1S1PR2
SCHEMBL7767973 0.92 S1PR1 (0.34) ITGB3ITGA2BS1PR3S1PR1S1PR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727428-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-06-06 EP disclosed
US-5665271-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-09-09 US disclosed
EP-0727428-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-08-21 EP disclosed