Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL7532651 | 0.87 | KDM4E (0.53) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL9575201 | 0.86 | CDC25B (0.45) | WDR5KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL4319334 | 0.84 | WDR5 (0.54) | WDR5KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL5028929 | 0.83 | WDR5 (0.41) | WDR5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3939222 | 0.82 | WDR5 (0.40) | WDR5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL23515370 | 0.80 | HSD17B10 (0.53) | WDR5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL29625744 | 0.80 | HSD17B10 (0.53) | WDR5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL14058648 | 0.80 | KDM4E (0.42) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL4665440 | 0.79 | WDR5 (0.38) | WDR5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6801208 | 0.79 | WDR5 (0.38) | WDR5KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873329-B1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-1081142-A2 | Novel N-Aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6015900-A | FOR TREATMENT OF PSYCHOTIC OR CENTRAL NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 2000-01-18 | — | — | US | disclosed |
| US-5932734-A | HIGH AFFINITY AND SELECTIVITY IN BINDING TO THE D3 RECEPTOR SUBTYPE; PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0873329-A1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5659033-A | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1997010229-A1 | NOVEL N-AMINOALKYLFLUORENECARBOXAMIDES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1997-03-20 | — | — | WO | disclosed |