Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 7/20 | 0.38 |
| ▸ | THRA | P10827 | 6/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052045 | 0.88 | NR3C1 (0.78) | NR3C1THRBTHRAAKR1C3AKR1C2 | |
| SCHEMBL7054015 | 0.86 | NR3C1 (0.66) | NR3C1THRBTHRAPOLBMAOB | |
| SCHEMBL7047606 | 0.77 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7054470 | 0.77 | NR3C1 (0.84) | NR3C1THRBTHRA | |
| SCHEMBL7052325 | 0.76 | NR3C1 (0.84) | NR3C1THRBTHRA | |
| SCHEMBL7054567 | 0.76 | NR3C1 (0.83) | NR3C1THRBTHRA | |
| SCHEMBL5632584 | 0.76 | NR3C1 (1.00) | NR3C1THRBTHRA | |
| SCHEMBL27565370 | 0.76 | NR3C1 (0.66) | NR3C1THRBTHRA | |
| SCHEMBL7048724 | 0.76 | NR3C1 (0.65) | NR3C1THRBTHRAPOLB | |
| SCHEMBL7050835 | 0.75 | NR3C1 (0.82) | NR3C1THRBTHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |