⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1766714 | 0.92 | — | — | |
| SCHEMBL7769338 | 0.90 | LMNA (0.42) | — | |
| SCHEMBL16244292 | 0.90 | LMNA (0.42) | — | |
| SCHEMBL995685 | 0.83 | — | — | |
| SCHEMBL2746597 | 0.83 | TSHR (0.52) | — | |
| SCHEMBL2745809 | 0.83 | LMNA (0.52) | — | |
| SCHEMBL2746089 | 0.80 | TSHR (0.50) | — | |
| Ammonia Solution, Strong SCHEMBL10897945 | 0.80 | LMNA (0.50) | — | |
| SCHEMBL5721317 | 0.80 | TSHR (0.50) | — | |
| SCHEMBL2136691 | 0.80 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978311-B | Cell apoptosis inhibitor and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2024-05-31 | — | — | CN | disclosed |
| CN-114874172-B | Oridonin derivative, preparation method and medical application thereof | 庞磊 | 2023-09-05 | — | — | CN | disclosed |
| CN-114874172-A | Oridonin derivative, preparation method and medical application thereof | 南充市中心医院 | 2022-08-09 | — | — | CN | disclosed |
| CN-112218867-A | Adenosine receptor antagonists and uses thereof | 泰昂治疗公司 | 2021-01-12 | — | — | CN | disclosed |
| CN-111978311-A | Apoptosis inhibitor and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2020-11-24 | — | — | CN | disclosed |
| US-9624232-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2017-04-18 | — | — | US | disclosed |
| CN-104271562-B | The diaminourea aryl derivatives replaced through carbamate and the Pesticidal combination comprising the derivative | 株式会社经农 | 2017-03-15 | — | — | CN | disclosed |
| US-9593124-B2 | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof | RHODES TECHNOLOGIES (US) | 2017-03-14 | — | — | US | disclosed |
| US-9556158-B2 | Fungicidal 3-[(pyridin-2-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,4-oxadiazol-5(2H)-one derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-01-31 | — | — | US | disclosed |
| US-9326515-B2 | Fungicidal 3-[(1,3-thiazol-4-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,4-oxadiazol-5(2H)-one derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-05-03 | — | — | US | disclosed |
| EP-2797891-A1 | FUNGICIDAL 3-[(PYRIDIN-2-YLMETHOXYIMINO)(PHENYL)METHYL]-2-SUBSTITUTED-1,2,4-OXADIAZOL-5(2H)-ONE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013098147-A1 | FUNGICIDAL 3-[(PYRIDIN-2-YLMETHOXYIMINO)(PHENYL)METHYL]-2-SUBSTITUTED-1,2,4-OXADIAZOL-5(2H)-ONE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-07-04 | — | — | WO | disclosed |
| EP-2298304-A2 | Carboline derivatives useful in the treatment of cancer | PTC Therapeutics, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| US-5691319-A | ANTICARCINOGENIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |
| EP-0536936-B1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | SANKYO CO (JP) | 1996-08-14 | — | — | EP | disclosed |
| EP-0536936-A1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | Sankyo Company Limited (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-4554372-A | FROM OXAZOLIDONE, HALOGEN AND OLEFIN | THE DOW CHEMICAL COMPANY (US) | 1985-11-19 | — | — | US | disclosed |