Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | CES2 | O00748 | 2/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL6392094 | 0.95 | ALDH1A1 (0.82) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL28512056 | 0.95 | ALDH1A1 (0.82) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL9436511 | 0.89 | ALDH1A1 (0.82) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL27629547 | 0.86 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL8661692 | 0.86 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL7454682 | 0.86 | ALDH1A1 (0.88) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL30536983 | 0.86 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL28491203 | 0.86 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL30537001 | 0.86 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 | |
| Benzophenone SCHEMBL6061130 | 0.86 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SRD5A2ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672718-B1 | Polyvinyl alcohol film, process for the production thereof and laminate | MITSUBISHI GAS CHEMICAL CO (JP) | 2001-06-06 | — | — | EP | disclosed |
| US-5582916-A | Polyvinyl alcohol film, process for the production thereof and laminate | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1996-12-10 | — | — | US | disclosed |
| EP-0672718-A1 | Polyvinyl alcohol film, process for the production thereof and laminate | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1995-09-20 | — | — | EP | disclosed |