Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900805 | 0.83 | TDP1 (0.59) | TDP1ABCB1ARPOLBMAPK1 | |
| SCHEMBL187068 | 0.78 | TDP1 (0.88) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL15298821 | 0.78 | TDP1 (0.88) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL7154355 | 0.78 | TDP1 (0.88) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL7146329 | 0.78 | TDP1 (0.88) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL7766967 | 0.75 | POLB (0.51) | TDP1POLBMAPK1MAPTLMNA | |
| SCHEMBL270042 | 0.75 | TDP1 (0.96) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL2175855 | 0.75 | TDP1 (0.96) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL7149374 | 0.75 | TDP1 (0.96) | TDP1ABCB1POLBMAPK1MAPT | |
| SCHEMBL7150717 | 0.75 | TDP1 (0.96) | TDP1ABCB1POLBMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| US-5830920-A | PREVENTION GROWTH OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |