Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 4/20 | 0.46 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7767503 | 1.00 | METAP1 (0.57) | METAP1MAOAMAOBCES2TNF | |
| SCHEMBL15698059 | 0.85 | CYP19A1 (0.48) | METAP1MAOAMAOBACHE | |
| SCHEMBL7767777 | 0.79 | MAOA (0.49) | MAOAMAOBCES2TNFACHE | |
| SCHEMBL1609651 | 0.79 | METAP1 (0.71) | METAP1MAOAMAOBACHECA1 | |
| SCHEMBL4808970 | 0.79 | MIF (0.61) | METAP1MAOAMAOBCES2ACHE | |
| SCHEMBL4808965 | 0.79 | MIF (0.61) | METAP1MAOAMAOBCES2ACHE | |
| SCHEMBL12034925 | 0.78 | MAOB (0.69) | METAP1MAOAMAOBCES2TNF | |
| SCHEMBL6056920 | 0.77 | METAP1 (0.69) | METAP1MAOAMAOBACHECA1 | |
| SCHEMBL1512741 | 0.76 | METAP1 (0.67) | METAP1MAOAMAOBACHECA1 | |
| SCHEMBL6056983 | 0.76 | METAP1 (0.67) | METAP1MAOAMAOBACHECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700905-B1 | Tricyclic pyrazole derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-5561150-A | 1-AMINOALKYL-1,4-DIHYDROINDENO(2,1-C)PYRAZOLES OR 1H-BENZ(G)INDAZOLES; SEROTONIN RECEPTOR ANTAGONISTS; ANTIDEPRESSANTS; NERVOUS SYSTEM, PSYCHOLOGICAL AND GASTROINTESTINAL DISORDERS | HOFFMAN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0700905-A1 | Tricyclic pyrazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1996-03-13 | — | — | EP | disclosed |