SCHEMBL7768544

SCHEMBL7768544

Nc1ccn(-c2ccc(Cl)cc2)c(=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 1.00
ALDH1A1 P00352 1/20 1.00
ALOX15 P16050 1/20 1.00
HTT P42858 1/20 1.00
SMN1; SMN2 Q16637 2/20 0.67
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
BIRC5 O15392 1/20 0.42
MGLL Q99685 1/20 0.39
POLB P06746 2/20 0.39
LCK P06239 1/20 0.39
KIT P10721 1/20 0.39
SRC P12931 1/20 0.39
KCNH2 Q12809 1/20 0.39
MCHR1 Q99705 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
APOBEC3G Q9HC16 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7765437 0.82 ALDH1A1 (0.70) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL7768468 0.81 ALDH1A1 (0.68) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL7768522 0.80 SMN1; SMN2 (1.00) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL7765476 0.77 ALDH1A1 (0.62) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL10059780 0.74 HTT (0.59) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL7763986 0.74 ALDH1A1 (0.59) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL8061746 0.73 SMN1; SMN2 (0.61) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL16862053 0.73 BIRC5 (0.59) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL13264081 0.73 ALDH1A1 (0.57) ATMALDH1A1ALOX15HTTSMN1; SMN2
SCHEMBL10059788 0.73 ALDH1A1 (0.57) ATMALDH1A1ALOX15HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1322197-A Novel 4-amino-1-arylpyridin-2-ones having anticonvulsant activity and process for preparing same DRESDEN ARZNEIMITTEL (DE) 2001-11-14 CN claimed
EP-1102748-A1 NEW 4-AMINO-1-ARYL-PYRIDINE-2-ONES WITH ANTICONVULSIVE ACTION AND METHOD FOR PRODUCING SAME ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-05-30 EP claimed
US-6071911-A A 1-PHENYL-2-OXO-4-AMINO, PIPERIDINO, MORPHOLINO OR PYRROLIDINO-1,2-DIHYDROPYRIDINE; ANTIEPILEPTIC AGENTS; ANTICONVULSANTS ARZNEIMITTELWERK DRESDEN GMBH (DE) 2000-06-06 US claimed
WO-2000007988-A1 NEW 4-AMINO-1-ARYL-PYRIDINE-2-ONES WITH ANTICONVULSIVE ACTION AND METHOD FOR PRODUCING SAME ARZNEIMITTELWERK DRESDEN GMBH (DE) 2000-02-17 WO claimed
CN-1322197-A Novel 4-amino-1-arylpyridin-2-ones having anticonvulsant activity and process for preparing same DRESDEN ARZNEIMITTEL (DE) 2001-11-14 CN disclosed
EP-1102748-A1 NEW 4-AMINO-1-ARYL-PYRIDINE-2-ONES WITH ANTICONVULSIVE ACTION AND METHOD FOR PRODUCING SAME ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-05-30 EP disclosed
US-6071911-A A 1-PHENYL-2-OXO-4-AMINO, PIPERIDINO, MORPHOLINO OR PYRROLIDINO-1,2-DIHYDROPYRIDINE; ANTIEPILEPTIC AGENTS; ANTICONVULSANTS ARZNEIMITTELWERK DRESDEN GMBH (DE) 2000-06-06 US disclosed
WO-2000007988-A1 NEW 4-AMINO-1-ARYL-PYRIDINE-2-ONES WITH ANTICONVULSIVE ACTION AND METHOD FOR PRODUCING SAME ARZNEIMITTELWERK DRESDEN GMBH (DE) 2000-02-17 WO disclosed