Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.56 |
| ▸ | MMP1 | P03956 | 15/20 | 0.56 |
| ▸ | MMP13 | P45452 | 9/20 | 0.56 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235053 | 1.00 | ADAM17 (0.56) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL7135335 | 0.90 | ADAM17 (0.67) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL6237689 | 0.90 | ADAM17 (0.67) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL6244941 | 0.90 | ADAM17 (0.59) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL6236221 | 0.85 | ADAM17 (0.51) | ADAM17MMP1MMP13 | |
| SCHEMBL6241443 | 0.85 | ADAM17 (0.56) | ADAM17MMP1MMP13 | |
| SCHEMBL7068818 | 0.84 | ADAM17 (0.49) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL6240560 | 0.84 | ADAM17 (0.49) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL7068813 | 0.84 | ADAM17 (0.49) | ADAM17MMP1MMP13MMP3MMP9 | |
| SCHEMBL6237728 | 0.83 | ADAM17 (0.50) | ADAM17MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-A1 | TACE INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009492-A1 | TACE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |