⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813924 | 0.92 | — | — | |
| SCHEMBL28689983 | 0.91 | LMNA (0.40) | — | |
| SCHEMBL22326320 | 0.90 | LMNA (0.42) | — | |
| SCHEMBL22326280 | 0.90 | LMNA (0.42) | — | |
| SCHEMBL5357389 | 0.90 | LMNA (0.42) | — | |
| SCHEMBL113903 | 0.83 | — | — | |
| SCHEMBL2746597 | 0.83 | TSHR (0.52) | — | |
| SCHEMBL2745809 | 0.83 | LMNA (0.52) | — | |
| SCHEMBL7297898 | 0.81 | — | — | |
| SCHEMBL5721317 | 0.80 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118440006-A | N-containing material2-Acyl-2-amino imidazole ring compound, preparation method and application thereof | 烟台新药创制山东省实验室 | 2024-08-06 | — | — | CN | disclosed |
| CN-116987045-A | Heteroatom-containing substituted benzoxazinone derivative and preparation method and application thereof | 中国医学科学院药物研究所 | 2023-11-03 | — | — | CN | disclosed |
| CN-116997449-A | Enhanced wood preservative containing zinc and boron | 阿萨达有限责任公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-108778273-B | Bicyclic aryl monocyclic beta-lactam compounds and methods of use thereof for treating bacterial infections | 默沙东公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-112996518-A | WD40 repeat domain protein 5(WDR5) degradation/disruption compounds and methods of use | 西奈山伊坎医学院 | 2021-06-18 | — | — | CN | disclosed |
| EP-3122346-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2020-07-15 | — | — | EP | disclosed |
| CN-108368040-A | Diaryl monocyclic β -lactam compounds and methods of use thereof for treating bacterial infections | 默沙东公司 | 2018-08-03 | — | — | CN | disclosed |
| US-9815846-B2 | TrkA kinase inhibitors, compositions and methods thereof | MERCK SHARP & DOHME CORP. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170114071-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-04-27 | — | — | US | disclosed |
| EP-3122346-A2 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| CN-103079553-B | Be used for the treatment of the N-acyl amino acid derivative of the skin disorder of such as liparitosis | HELIX BIOMEDIX INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| WO-2015148344-A2 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| CN-103079553-A | N-acyl amino acid derivatives for treating skin conditions such as cellulite | HELIX BIOMEDIX INC | 2013-05-01 | — | — | CN | disclosed |
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| US-5691319-A | ANTICARCINOGENIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |
| EP-0536936-B1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | SANKYO CO (JP) | 1996-08-14 | — | — | EP | disclosed |
| EP-0536936-A1 | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use | Sankyo Company Limited (JP) | 1993-04-14 | — | — | EP | disclosed |