⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL310497 | 0.98 | EGFR (0.34) | — | |
| Hydrochloric Acid SCHEMBL311767 | 0.98 | EGFR (0.34) | — | |
| SCHEMBL3882732 | 0.89 | RPS6KA5 (0.32) | — | |
| Ether SCHEMBL438449 | 0.87 | PDE5A (0.30) | — | |
| Acetamide SCHEMBL9934178 | 0.86 | ENPP1 (0.31) | — | |
| SCHEMBL2350790 | 0.76 | KDM4E (0.44) | — | |
| Allopurinol SCHEMBL3424531 | 0.75 | XDH (0.61) | — | |
| SCHEMBL29809882 | 0.72 | EGFR (0.46) | — | |
| SCHEMBL140301 | 0.72 | EGFR (0.46) | — | |
| SCHEMBL11024535 | 0.71 | EGFR (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3676 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545682-B2 | Heterocyclic derivatives as P2X7 receptor antagonists | BREYE THERAPEUTICS APS (DK) | 2026-02-10 | — | — | US | claimed |
| EP-3590516-B1 | ANTITUMOR-EFFECT ENHANCER USING PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND | TAIHO PHARMACEUTICAL CO LTD (JP) | 2025-09-03 | — | — | EP | claimed |
| EP-4568972-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119679800-A | Application of 2H-pyrazolo [3,4-d ] pyrimidine derivative in preparation of medicines for preventing, relieving, treating and/or assisting in treating non-alcoholic steatohepatitis | 天津济坤医药科技有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119654326-A | Novel heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2025-03-18 | — | — | CN | claimed |
| EP-4262975-B1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | BREYE THERAPEUTICS APS (DK) | 2025-03-05 | — | — | EP | claimed |
| US-12186320-B2 | Therapeutic agent containing pyrazolo[3,4-d]pyrimidine compound as active ingredient | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2025-01-07 | — | — | US | claimed |
| EP-3845231-B1 | THERAPEUTIC AGENT CONTAINING PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND AS ACTIVE INGREDIENT | TAIHO PHARMACEUTICAL CO LTD (JP) | 2025-01-01 | — | — | EP | claimed |
| WO-2024033277-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | claimed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | claimed |
| WO-1992003577-A1 | OLIGO(ALPHA-ARABINOFURANOSYL NUCLEOTIDES) AND ALPHA-ARABINOFURANOSYL PRECURSORS THEREOF | MICROPROBE CORPORATION (US) | 1992-03-05 | — | — | WO | claimed |
| WO-1990003370-A1 | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE | MICROPROBE CORPORATION (US) | 1990-04-05 | — | — | WO | claimed |
| US-4904666-A | Pyrazolo(3,4-d)pyrimidine compounds, compositions and method of use | BOEHRINGER MANNHEIM GMBH (DE) | 1990-02-27 | — | — | US | claimed |
| US-4511557-A | CALF'S BLOOD DIAYSATE AS VASODILATION POTENTIATOR | GAURI KAILASH KUMAR (DE) | 1985-04-16 | — | — | US | claimed |
| EP-0106309-A2 | Biologically active extracts, process for their manufacture, medicinal and cosmetical preparations comprising them, and their use as additives in foodstuffs and stimulants | Gauri, Kailash Kumar, Dr. Prof. (DE) | 1984-04-25 | — | — | EP | claimed |
| EP-0077372-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-d)PYRIMIDINE, PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-04-27 | — | — | EP | claimed |
| WO-1982003626-A1 | NEW DERIVATIVES OF PYRAZOLO(3,4-D)PYRIMIDINE,PREPARATION METHOD THEREOF AND REMEDY CONTAINING THEM | GAURI KAILASH KUMAR | 1982-10-28 | — | — | WO | claimed |
| EP-0063381-A1 | Pyrazolo(3-4-d) pyrimidines, process for their preparation and pharmaceutical compositions containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-10-27 | — | — | EP | claimed |
| US-4001230-A | ANTIBACTERIAL, ANTIPROTAZOAL | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | claimed |