Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.69 |
| ▸ | CDK2 | P24941 | 13/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387518 | 0.93 | CDK4 (0.82) | CDK4CDK2CCNE1 | |
| SCHEMBL7775688 | 0.86 | KDM4E (0.54) | CDK4CDK2EGFR | |
| SCHEMBL7775630 | 0.81 | EGFR (0.54) | CDK4CDK2CCNE1EGFR | |
| SCHEMBL7777479 | 0.80 | EGFR (0.53) | CDK4EGFR | |
| SCHEMBL23752463 | 0.77 | CDK4 (1.00) | CDK4CDK2CCNE1 | |
| SCHEMBL23752462 | 0.77 | CDK4 (1.00) | CDK4CDK2CCNE1 | |
| SCHEMBL23752603 | 0.77 | CDK4 (1.00) | CDK4CDK2CCNE1 | |
| SCHEMBL1387302 | 0.75 | EGFR (0.72) | HIF1AEGFR | |
| SCHEMBL7777484 | 0.75 | EGFR (0.56) | EGFR | |
| SCHEMBL7771258 | 0.74 | EGFR (0.55) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |