Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 9/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771237 | 0.86 | CDK4 (0.69) | EGFRCDK4CDK2 | |
| SCHEMBL1387518 | 0.78 | CDK4 (0.82) | CDK4CDK2 | |
| SCHEMBL7771258 | 0.77 | EGFR (0.55) | EGFRTNNI3KERBB3MEN1NPC1 | |
| SCHEMBL1387302 | 0.76 | EGFR (0.72) | EGFRTNNI3KERBB3MEN1NPC1 | |
| SCHEMBL7777484 | 0.76 | EGFR (0.56) | EGFRTNNI3KERBB3MEN1NPC1 | |
| SCHEMBL7775630 | 0.74 | EGFR (0.54) | EGFRCDK4TNNI3KERBB3MEN1 | |
| SCHEMBL7777251 | 0.74 | EGFR (0.59) | EGFRTNNI3KERBB3MEN1NPC1 | |
| SCHEMBL7777479 | 0.74 | EGFR (0.53) | KDM4EEGFRCDK4TNNI3KERBB3 | |
| SCHEMBL7775622 | 0.73 | ALDH1A1 (0.52) | EGFRTNNI3KERBB3MEN1NPC1 | |
| SCHEMBL13736891 | 0.72 | MAPT (0.68) | KDM4EADRB2ADRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |