Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775673 | 0.90 | EGFR (0.57) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL2837168 | 0.87 | EGFR (0.56) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL691545 | 0.87 | EGFR (0.51) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL7776032 | 0.87 | EGFR (0.55) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL7775667 | 0.86 | EGFR (0.60) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL7777468 | 0.84 | EGFR (0.74) | EGFRERBB3TNNI3KMAPK1AURKA | |
| SCHEMBL690919 | 0.83 | NPC1 (0.55) | EGFRERBB3MAPK1GRM1AURKA | |
| SCHEMBL1387327 | 0.82 | APP (0.62) | EGFRERBB3TNNI3KMAPK1GRM1 | |
| SCHEMBL1095277 | 0.82 | MAPK1 (0.61) | EGFRERBB3MAPK1GRM1AURKA | |
| SCHEMBL691649 | 0.81 | EGFR (0.55) | EGFRERBB3MAPK1GRM1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |