Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771255 | 0.87 | EGFR (0.62) | EGFRTNNI3KERBB3MAPK1KDR | |
| SCHEMBL1387327 | 0.87 | APP (0.62) | EGFRTNNI3KERBB3RAPGEF4MAPK1 | |
| SCHEMBL691545 | 0.86 | EGFR (0.51) | EGFRTNNI3KERBB3MAPK1ERBB2 | |
| SCHEMBL7775673 | 0.86 | EGFR (0.57) | EGFRTNNI3KERBB3MAPK1KDR | |
| SCHEMBL1387302 | 0.84 | EGFR (0.72) | EGFRTNNI3KERBB3MAPK1ERBB2 | |
| SCHEMBL2837168 | 0.84 | EGFR (0.56) | EGFRTNNI3KERBB3MAPK1ERBB2 | |
| SCHEMBL7777468 | 0.83 | EGFR (0.74) | EGFRTNNI3KFGFR1ERBB3MAPK1 | |
| SCHEMBL7775667 | 0.83 | EGFR (0.60) | EGFRTNNI3KERBB3MAPK1APP | |
| SCHEMBL7777514 | 0.82 | TNNI3K (0.53) | EGFRTNNI3KRAPGEF4MAPK1KDR | |
| SCHEMBL2782010 | 0.81 | EGFR (0.65) | EGFRTNNI3KERBB3ERBB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |