Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771278 | 0.92 | MEN1 (0.51) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL9255895 | 0.79 | ALDH1A1 (0.77) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL2503879 | 0.79 | ALDH1A1 (0.77) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL31677374 | 0.79 | ALDH1A1 (0.77) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL29374356 | 0.79 | ALDH1A1 (0.77) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL1387302 | 0.78 | EGFR (0.72) | HIF1AEGFRMEN1NPC1RAB9A | |
| SCHEMBL23868689 | 0.77 | ALDH1A1 (0.64) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL8262888 | 0.77 | ALDH1A1 (0.68) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL7775630 | 0.76 | EGFR (0.54) | EGFRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL13948481 | 0.76 | ALDH1A1 (0.70) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |