Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 8/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223927 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6220795 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6220562 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6224875 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6224872 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6220557 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6220793 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6223932 | 1.00 | ADAM17 (0.45) | ADAM17GRIK1GRIK2HTR2APAM | |
| SCHEMBL6220502 | 0.88 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2AMAPT | |
| SCHEMBL6220493 | 0.88 | ADAM17 (0.48) | ADAM17GRIK1GRIK2HTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |