Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6277631 | 1.00 | PTGS1 (0.53) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6282924 | 0.86 | MAPT (0.58) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6319806 | 0.86 | MAPT (0.58) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6277561 | 0.86 | MAPT (0.58) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1883565 | 0.73 | MAPT (0.64) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1883564 | 0.73 | MAPT (0.64) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7488737 | 0.72 | PTGS1 (0.76) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31441027 | 0.72 | PTGS1 (0.76) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL23391005 | 0.72 | PTGS1 (0.76) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 0.71 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | disclosed |