Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 2/20 | 1.00 |
| ▸ | CXCR2 | P25025 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL2896 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL195303 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8577572 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL29396875 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL16757741 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL66987 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL29353694 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL3843886 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8754790 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL23391019 | 0.98 | PTGS1 (0.97) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2025 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545750-B2 | Method for the diimide hydrogenation of emulsified unsaturated polymers | PARKER DANE K (US) | 2026-02-10 | — | — | US | claimed |
| EP-4673452-A1 | PHOTOBASES | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2026-01-07 | — | — | EP | claimed |
| EP-3829662-B1 | MATERIAL AND METHOD FOR PRODUCING CELL RECEIVING SCAFFOLD | LUNG BIOTECHNOLOGY PBC (US) | 2025-08-20 | — | — | EP | claimed |
| US-12285396-B2 | Co-crystal of ketoprofen, compositions comprising the same, process of producing the same, and uses thereof | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2025-04-29 | — | — | US | claimed |
| CN-116731652-B | Single-component yellowing-resistant ultraviolet light delay curing type Mini LED epoxy packaging adhesive and preparation method thereof | 信泰永合(烟台)新材料有限公司 | 2025-04-15 | — | — | CN | claimed |
| US-12187851-B2 | Network polymers and methods of making and using same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2025-01-07 | — | — | US | claimed |
| WO-2024180096-A1 | PHOTOBASES | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2024-09-06 | — | — | WO | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-116731375-A | Polymer surface modification method, obtained surface modified polymer and application thereof | 中国科学院赣江创新研究院 | 2023-09-12 | — | — | CN | claimed |
| CN-116731652-A | Single-component yellowing-resistant ultraviolet light delay curing type Mini LED epoxy packaging adhesive and preparation method thereof | 信泰永合(烟台)新材料有限公司 | 2023-09-12 | — | — | CN | claimed |
| US-4268685-A | Salicylamide esters and related pharmaceutical composition | NEOPHARMED S.P.A. (IT) | 1981-05-19 | — | — | US | claimed |
| US-4260613-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC | CRINOS INDUSTRIA FARMACOBIOLOGICA S.P.A. (IT) | 1981-04-07 | — | — | US | claimed |
| US-4233315-A | M-BENZOYLHYDRATROPIC ACID AND ACETAMINOPHEN | MCNEILAB, INC. (US) | 1980-11-11 | — | — | US | claimed |
| US-4230884-A | METHYLATION, HYDROLYSIS, WITH CATALYST | LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) | 1980-10-28 | — | — | US | claimed |
| EP-0017169-A1 | Improved anti-inflammatory combinations having reduced ulcerogenicity | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | claimed |
| EP-0016460-A1 | Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition | NEOPHARMED S.p.A. (IT) | 1980-10-01 | — | — | EP | claimed |
| EP-0012621-A1 | Analgesic composition comprising acetaminophen as a potentiating agent | McNeilab, Inc. (US) | 1980-06-25 | — | — | EP | claimed |
| US-4201870-A | Process for the preparation of 2-(3-benzoylphenyl)-propionic acid | LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) | 1980-05-06 | — | — | US | claimed |
| US-4162364-A | ANTIINFLAMMATORY AGENT | LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) | 1979-07-24 | — | — | US | claimed |
| US-4097522-A | Synthesis of m-benzoyl-hydratropic acid | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1978-06-27 | — | — | US | claimed |