Bromide

Bromide

SCHEMBL7776359

Br.CC(C)(c1ccccc1)c1ccccc1N

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
ALDH1A1 P00352 2/20 0.43
ESR1 P03372 2/20 0.43
ESR2 Q92731 2/20 0.43
TAAR1 Q96RJ0 1/20 0.40
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALOX15 P16050 2/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38
KCNN4 O15554 3/20 0.37
NR3C2 P08235 3/20 0.35
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3751989 0.98 CYP3A4 (0.45) CYP3A4ALDH1A1ESR1ESR2TAAR1
Hydrochloric Acid SCHEMBL3291595 0.96 CYP3A4 (0.43) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL2034203 0.91 CYP3A4 (0.41) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL10392513 0.85 S1PR1 (0.39) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL9187894 0.85 ESR1 (0.44) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL895143 0.84 CYP3A4 (0.47) CYP3A4ALDH1A1SMN1; SMN2ALOX15CASP1
SCHEMBL30606647 0.83 CYP3A4 (0.41) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL4409081 0.83 CYP3A4 (0.41) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL2199266 0.81 ALDH1A1 (0.54) CYP3A4ALDH1A1ESR1ESR2TAAR1
SCHEMBL565208 0.80 ESR1 (0.47) CYP3A4ALDH1A1ESR1ESR2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634407-B1 Process for production of tris(tribromophenoxy)-s-triazine DAI ICHI KOGYO SEIYAKU CO LTD (JP) 2001-10-10 EP disclosed
US-6075142-A CATALYTICALLY REACTING CYANURIC CHLORIDE AND AQUEOUS TRIBROMOPHENOLATE SOLUTION CONTAINING A REDUCING AGENT AND A PHASE TRANSFER CATALYST TO FORM TRIS/TRIBROMOPHENOXY/-S-TRAIZINE DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 2000-06-13 US disclosed
EP-0735084-B1 Flame retardant thermoplastic styrenic resin composition DAI ICHI KOGYO SEIYAKU CO LTD (JP) 2000-01-12 EP disclosed
EP-0633253-B1 Process for production of tris(tribromophenoxy)-s-triazine DAI ICHI KOGYO SEIYAKU CO LTD (JP) 1999-09-01 EP disclosed
US-5907040-A REACTION OF CYANURIC CHLORIDE WITH BROMOPHENOL AND TERT-AMINECATALYSTS DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 1999-05-25 US disclosed
US-5696302-A INTERMEDIATES FOR PRODUCING TRIS(TRIBROMOPHENOXY)-S-TRIAZINE DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 1997-12-09 US disclosed
US-5498714-A FROM CYANURIC CHLORIDE AND TRIBROMOPHENOLATE, PHASE TRANSFER AGENT, REDUCING AGENT TO PREVENT POLYMERIZATION DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 1996-03-12 US disclosed
EP-0634407-A1 Process for production of tris(tribromophenoxy)-s-triazine DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 1995-01-18 EP disclosed
EP-0633253-A1 Process for production of tris(tribromophenoxy)-s-triazine DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) 1995-01-11 EP disclosed