Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PER2 | O15055 | 3/20 | 0.31 |
| ▸ | CRY1 | Q16526 | 3/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776527 | 0.88 | SLC22A12 (0.38) | SLC22A12PTGDR2ALOX15HTR2AHTR2C | |
| SCHEMBL7777106 | 0.88 | SLC22A12 (0.37) | SLC22A12ALOX15HTR2AHTR2C | |
| SCHEMBL7779340 | 0.87 | SLC22A12 (0.36) | SLC22A12PTGDR2 | |
| Fumaric Acid SCHEMBL5678027 | 0.78 | SLC22A12 (0.45) | SLC22A12KDM4CPTGDR2ALOX15HTR2A | |
| Fumaric Acid SCHEMBL5678044 | 0.78 | SLC22A12 (0.45) | SLC22A12KDM4CPTGDR2ALOX15HTR2A | |
| SCHEMBL7778328 | 0.76 | ADORA2A (0.34) | SLC22A12 | |
| SCHEMBL5678034 | 0.76 | PTGDR2 (0.34) | SLC22A12PTGDR2HTR2AHTR2CRBP4 | |
| SCHEMBL7777139 | 0.74 | SLC22A12 (0.39) | SLC22A12HTR2AHTR2C | |
| SCHEMBL7778389 | 0.73 | SLC22A12 (0.35) | SLC22A12 | |
| Fumaric Acid SCHEMBL5678039 | 0.71 | SLC22A12 (0.47) | SLC22A12KDM4CPTGDR2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129078-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000012481-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY________________ | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |