Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7776530 | 0.87 | SLC22A12 (0.37) | SLC22A12PTGDR2 | |
| SCHEMBL7776527 | 0.86 | SLC22A12 (0.38) | SLC22A12PTGDR2AKR1B1 | |
| SCHEMBL7777106 | 0.85 | SLC22A12 (0.37) | SLC22A12 | |
| Fumaric Acid SCHEMBL5678111 | 0.79 | SLC22A12 (0.43) | SLC22A12PTGDR2PTGER1AKR1B1NPSR1 | |
| Fumaric Acid SCHEMBL5678122 | 0.79 | SLC22A12 (0.43) | SLC22A12PTGDR2PTGER1AKR1B1NPSR1 | |
| SCHEMBL5678114 | 0.77 | DPP7 (0.34) | SLC22A12PTGDR2PTGER1AKR1B1NPSR1 | |
| SCHEMBL905944 | 0.76 | HTR2A (0.48) | SLC22A12 | |
| Fumaric Acid SCHEMBL5678117 | 0.73 | SLC22A12 (0.45) | SLC22A12PTGDR2PTGER1AKR1B1 | |
| SCHEMBL5679817 | 0.72 | PPARG (0.36) | SLC22A12PTGDR2CRHR1 | |
| SCHEMBL5679829 | 0.72 | PPARG (0.36) | SLC22A12PTGDR2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129078-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RESEARCH LIMITED (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000012481-A2 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY________________ | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |