SCHEMBL7778331

SCHEMBL7778331

CN(C)CCCc1cc(NNc2nccn2C(C)(C)C)cc(C(F)(F)F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.38
TEK Q02763 1/20 0.38
NOS1 P29475 4/20 0.33
NOS2 P35228 3/20 0.33
TACR1 P25103 2/20 0.33
CCR2 P41597 2/20 0.32
LMNA P02545 2/20 0.32
GAA P10253 1/20 0.32
NOS3 P29474 3/20 0.31
TP53 P04637 2/20 0.31
NPC1 O15118 1/20 0.31
ABCB11 O95342 1/20 0.31
CYP1A2 P05177 1/20 0.31
CHRM2 P08172 1/20 0.31
ABCB1 P08183 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
CYP2D6 P10635 1/20 0.31
CHRM1 P11229 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7778334 0.77 NOS1 (0.34) KDRTEKNOS1NOS2TACR1
SCHEMBL22028466 0.71 TACR1 (0.52) NOS1NOS2TACR1CCR2LMNA
SCHEMBL15077165 0.69 KCNH2 (0.51) NOS1NOS2TACR1CCR2LMNA
SCHEMBL10104415 0.66 TACR1 (0.45) NOS1NOS2TACR1CCR2NOS3
SCHEMBL445763 0.65 TACR1 (0.44) NOS1NOS2TACR1CCR2NOS3
SCHEMBL24071085 0.65 CYP1A2 (0.48) KDRTEKTACR1LMNAGAA
SCHEMBL7866871 0.65 GAA (0.44) KDRTEKTACR1CCR2LMNA
Hydrochloric Acid SCHEMBL787937 0.64 TACR1 (0.43) NOS1NOS2TACR1CCR2NOS3
SCHEMBL7645151 0.62 GAA (0.44) KDRTEKTACR1LMNAGAA
SCHEMBL14117184 0.62 KCNH2 (0.38) TACR1CCR2LMNAGAACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144397-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144397-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034258-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed