SCHEMBL7778415

SCHEMBL7778415

Cc1cccc([Si](Cl)(Cl)Cl)c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.44
ATM Q13315 1/20 0.44
CYP1A2 P05177 3/20 0.39
CYP2A6 P11509 2/20 0.39
TSHR P16473 3/20 0.38
ACHE P22303 1/20 0.38
ALDH1A1 P00352 2/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
KEAP1 Q14145 1/20 0.34
NFE2L2 Q16236 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CD44 P16070 1/20 0.33
MAPT P10636 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.33
CYP3A4 P08684 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1318674 0.87 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1313855 0.85 TRPA1 (0.41) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1317885 0.85 TRPA1 (0.41) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL2785323 0.81 TSHR (0.47) CYP1A2CYP2A6TSHRACHEALDH1A1
SCHEMBL1313994 0.80 TRPA1 (0.37) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL986311 0.79 TRPA1 (0.44) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1315179 0.78 TRPA1 (0.35) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1315860 0.78 TRPA1 (0.35) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1316141 0.78 TRPA1 (0.35) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL1686740 0.77 TRPA1 (0.48) TRPA1ATMCYP1A2CYP2A6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3253770-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-09-02 EP disclosed
EP-3253771-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-08-12 EP disclosed
US-20190332010-A1 ENERGY-SENSITIVE COMPOSITION, CURED PRODUCT, AND PATTERN FORMING METHOD TOKYO OHKA KOGYO CO., LTD. (JP) 2019-10-31 US disclosed
US-9908903-B2 Method of producing organohalosilanes DOW CORNING CORPORATION (US) 2018-03-06 US disclosed
US-20170369514-A1 Method Of Producing Organohalosilanes DOW SILICONES CORPORATION 2017-12-28 US disclosed
CN-107223127-A Method for producing organohalosilanes 美国道康宁公司 2017-09-29 CN disclosed
CN-107206355-A The method for preparing organo-halogen-silane 美国道康宁公司 2017-09-26 CN disclosed
WO-2016126804-A1 METHOD OF PRODUCING ORGANOHALOSILANES DOW CORNING CORPORATION (US) 2016-08-11 WO disclosed
WO-2016126808-A1 METHOD OF PRODUCING ORGANOHALOSILANES DOW CORNING CORPORATION (US) 2016-08-11 WO disclosed
CN-1126653-C Method for manufacturing article having predetermined surface shape, and optical waveguide element NIPPON SHEET GLASS CO LTD (JP) 2003-11-05 CN disclosed
CN-1321117-A Method for manufacturing article having predetermined surface shape, and optical waveguide element NIPPON SHEET GLASS CO LTD (JP) 2001-11-07 CN disclosed
EP-1142682-A1 METHOD FOR PRODUCING ARTICLE HAVING PREDETERMINED SURFACE SHAPE, AND OPTICAL WAVEGUIDE ELEMENT Nippon Sheet Glass Co., Ltd. (JP) 2001-10-10 EP disclosed
EP-0076656-B1 SOLVENT-SOLUBLE ORGANOPOLYSILSESQUIOXANES, PROCESSES FOR PRODUCING THE SAME, AND COMPOSITIONS AND SEMICONDUCTOR DEVICES USING THE SAME JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1988-06-01 EP disclosed
US-4626556-A LADDER POLYMERS JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1986-12-02 US disclosed
EP-0076656-A2 Solvent-soluble organopolysilsesquioxanes, processes for producing the same, and compositions and semiconductor devices using the same JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-04-13 EP disclosed
US-4099981-A MINERAL FILLER UNION CARBIDE CORPORATION (US) 1978-07-11 US disclosed
US-4044037-A COUPLING AGENTS UNION CARBIDE CORPORATION (US) 1977-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190332010-A1 ENERGY-SENSITIVE COMPOSITION, CURED PRODUCT, AND PATTERN FORMING METHOD KCNQ5, CACNA1A, KCNQ1 TRPA1 91/4885ATM 2009/4885CYP1A2 4167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.