Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.55 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.50 |
| ▸ | KRAS | P01116 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7773684 | 0.83 | EGFR (0.57) | EGFRSOS1KRASKDRRET | |
| SCHEMBL7778224 | 0.82 | EGFR (0.54) | EGFRSOS1KRASKDRRET | |
| SCHEMBL7778512 | 0.81 | EGFR (0.53) | EGFRSOS1KRASKDRRET | |
| SCHEMBL7773707 | 0.81 | EGFR (0.53) | EGFRSOS1KRASKDRRET | |
| SCHEMBL7778562 | 0.78 | EGFR (0.50) | EGFRSOS1KRASKDRRET | |
| SCHEMBL7778258 | 0.73 | EGFR (0.45) | EGFRSOS1KRASKDRAURKA | |
| SCHEMBL7773665 | 0.73 | LMNA (0.46) | BRD4LMNAHTT | |
| SCHEMBL7773701 | 0.73 | EGFR (0.70) | EGFRSOS1KRASKDRRET | |
| SCHEMBL27537381 | 0.71 | EGFR (1.00) | EGFRSOS1KRASKDRRET | |
| SCHEMBL5864606 | 0.67 | EGFR (1.00) | EGFRKDRRETLCKFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | claimed |
| US-6057326-A | USED FOR TREATING EPIDERMAL HYPERPROLIFERATION, AS AN ANTI-METASTATIC OR ANTI-CANCER AGENT, TO CONTROL ANGIOGENESIS, INHIBIT DEVELOPMENT OF ATHEROMATOUS PLAQUE, TREATING ALZHEIMER'S DISEASE, OR AS AN IMMUNOMODULATING AGENT | PHARMACIA & UPJOHN S.P.A (IT) | 2000-05-02 | — | — | US | claimed |
| EP-0853616-B1 | BICYCLIC 4-ARALKYLAMINOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-19 | — | — | EP | disclosed |
| US-6057326-A | USED FOR TREATING EPIDERMAL HYPERPROLIFERATION, AS AN ANTI-METASTATIC OR ANTI-CANCER AGENT, TO CONTROL ANGIOGENESIS, INHIBIT DEVELOPMENT OF ATHEROMATOUS PLAQUE, TREATING ALZHEIMER'S DISEASE, OR AS AN IMMUNOMODULATING AGENT | PHARMACIA & UPJOHN S.P.A (IT) | 2000-05-02 | — | — | US | disclosed |