Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617028 | 0.86 | KDM4E (0.55) | KDM4ETHRBTSHRMEN1KMT2A | |
| SCHEMBL14278873 | 0.83 | KDM4E (0.42) | KDM4ETSHRMEN1KMT2AP2RX3 | |
| SCHEMBL7298238 | 0.83 | KDM4E (0.42) | KDM4ETSHRMEN1KMT2AP2RX3 | |
| SCHEMBL7778652 | 0.83 | KDM4E (0.42) | KDM4ETSHRMEN1KMT2AP2RX3 | |
| SCHEMBL162146 | 0.83 | THRB (0.40) | KDM4ETHRBTSHRMEN1KMT2A | |
| SCHEMBL8474662 | 0.81 | MAPT (0.46) | KDM4ETSHRMEN1KMT2AP2RX3 | |
| SCHEMBL3279037 | 0.81 | KDM4E (0.47) | KDM4ETHRBTSHRMEN1KMT2A | |
| SCHEMBL19015373 | 0.80 | KDM4E (0.40) | KDM4ETSHRMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11700040 | 0.79 | KDM4E (0.50) | KDM4ETHRBTSHRMEN1KMT2A | |
| SCHEMBL7298228 | 0.78 | KDM4E (0.39) | KDM4ETSHRMEN1KMT2AP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |