Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 4/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330554 | 1.00 | CXCR1 (0.55) | CXCR1CXCR2PTGS2CHRM1PDE4A | |
| SCHEMBL6320504 | 0.85 | CXCR1 (0.53) | CXCR1CXCR2PTGS2CHRM1PDE4A | |
| SCHEMBL27568101 | 0.83 | HPGD (0.53) | PTGS2LMNARAB9APTGS1CYP2C9 | |
| SCHEMBL7154919 | 0.81 | PTGS1 (0.49) | PTGS2LMNATRPV1PTGS1ALOX5 | |
| SCHEMBL27568086 | 0.81 | PTGS1 (0.49) | PTGS2LMNATRPV1PTGS1ALOX5 | |
| SCHEMBL27547914 | 0.81 | PTGS1 (0.52) | CXCR1CXCR2PTGS2MAPTLMNA | |
| SCHEMBL7159171 | 0.81 | PTGS1 (0.52) | CXCR1CXCR2PTGS2MAPTLMNA | |
| SCHEMBL6281212 | 0.78 | CXCR1 (0.67) | CXCR1CXCR2PTGS2CHRM1PDE4A | |
| SCHEMBL27573450 | 0.77 | CXCR1 (0.68) | CXCR1CXCR2PTGS2CHRM1PDE4A | |
| SCHEMBL1114395 | 0.77 | PTGS1 (0.53) | CXCR1CXCR2PTGS2LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | disclosed |