Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405319 | 0.81 | PPARA (0.71) | NPSR1GAAPPARAPPARGSMN1; SMN2 | |
| SCHEMBL15922116 | 0.81 | PPARA (0.71) | NPSR1GAAPPARAPPARGSMN1; SMN2 | |
| SCHEMBL12869146 | 0.79 | PPARA (0.69) | NPSR1GAAPPARAPPARGTHRB | |
| SCHEMBL7408448 | 0.78 | KMT2A (0.66) | NPSR1GAAPOLBSMN1; SMN2MMP1 | |
| SCHEMBL11817150 | 0.77 | PPARA (0.63) | NPSR1GAAPPARAPPARGALDH1A1 | |
| SCHEMBL2346864 | 0.77 | GAA (0.77) | NPSR1GAAPOLBSMN1; SMN2TSHR | |
| SCHEMBL11364339 | 0.77 | PPARA (0.51) | NPSR1GAAPPARAPPARGPOLB | |
| SCHEMBL11366850 | 0.77 | PPARA (0.51) | NPSR1GAAPPARAPPARGPOLB | |
| SCHEMBL9651741 | 0.77 | PPARA (0.67) | NPSR1GAAPPARAPPARGALDH1A1 | |
| SCHEMBL8798490 | 0.77 | CA12 (0.58) | NPSR1GAAPPARGPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |