Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL31684165 | 0.92 | GRIK1 (0.46) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| D-Aspartate SCHEMBL2791360 | 0.84 | GRIK1 (0.50) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| Aspartic Acid SCHEMBL7422755 | 0.83 | GRIK1 (0.49) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| Aspartic Acid SCHEMBL7422749 | 0.83 | GRIK1 (0.49) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| Aspartic Acid SCHEMBL27975470 | 0.83 | GRIK1 (0.49) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| Aspartic Acid SCHEMBL7422744 | 0.83 | GRIK1 (0.49) | GRIK1GRIK2ALDH1A1GRM2DPP7 | |
| Biphenyl SCHEMBL7781977 | 0.81 | GRM8 (0.67) | GRIK1GRIK2GRM2DPP7GRIA1 | |
| Aspartic Acid SCHEMBL11065185 | 0.80 | GRIK1 (0.56) | GRIK1GRIK2GRM2GRIA1GRIA2 | |
| Aspartic Acid SCHEMBL11065189 | 0.80 | GRIK1 (0.56) | GRIK1GRIK2GRM2GRIA1GRIA2 | |
| Aspartic Acid SCHEMBL996424 | 0.80 | GRIK1 (0.56) | GRIK1GRIK2GRM2GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135398-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | Monsanto Technology LLC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6218563-B1 | Cyanophosphonamides and method for preparation | MONSANTO COMPANY | 2001-04-17 | — | — | US | disclosed |
| WO-2000032611-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | MONSANTO TECHNOLOGY LLC (US) | 2000-06-08 | — | — | WO | disclosed |