Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.39 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL7422744 | 1.00 | GRIK1 (0.49) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| Aspartic Acid SCHEMBL27975470 | 1.00 | GRIK1 (0.49) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| Aspartic Acid SCHEMBL7422755 | 1.00 | GRIK1 (0.49) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| Serine SCHEMBL10579332 | 0.84 | ALDH1A1 (0.44) | GRIK1ALDH1A1GRIK2HSD17B10THRB | |
| Serine SCHEMBL10579320 | 0.84 | ALDH1A1 (0.44) | GRIK1ALDH1A1GRIK2HSD17B10THRB | |
| Biphenyl SCHEMBL7779237 | 0.83 | GRIK1 (0.53) | GRIK1ALDH1A1GRIK2DPP7DPP4 | |
| Glutamic Acid SCHEMBL27975498 | 0.83 | GRM8 (0.60) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| D-Glutamate SCHEMBL27975473 | 0.83 | GRM8 (0.60) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| Leucine SCHEMBL3724837 | 0.83 | SLC7A5 (0.60) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 | |
| Leucine SCHEMBL3724834 | 0.83 | SLC7A5 (0.60) | GRIK1ALDH1A1GRIK2HSD17B10DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993006127-A1 | NOVEL AMINO ACID PRODRUG RENIN INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-04-01 | — | — | WO | disclosed |