Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698683 | 0.88 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL13236931 | 0.83 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL28795717 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL8122808 | 0.75 | PTGS2 (0.75) | PTGS2PTGS1PDPK1CHRNA7CYP2C9 | |
| SCHEMBL3240313 | 0.75 | PTGS2 (1.00) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL5205228 | 0.74 | PTGS2 (0.67) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL7652652 | 0.74 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL8120395 | 0.73 | PTGS2 (0.75) | PTGS2PTGS1PDPK1CHRNA7CYP2C9 | |
| SCHEMBL8121607 | 0.73 | PTGS2 (0.74) | PTGS2PTGS1PDPK1CHRNA7CYP2C9 | |
| SCHEMBL8120747 | 0.73 | PTGS2 (0.74) | PTGS2PTGS1PDPK1CHRNA7CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772597-B1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1127878-A1 | 3,4 - substituted pyrazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6028072-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0772597-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5580985-A | ANTIARTHRITIC AGENT; SIDE EFFECT REDUCTION | G. D. SEARLE & CO. (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1996003385-A1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
| US-5486534-A | 3,4-substituted pyrazoles for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-01-23 | — | — | US | disclosed |