Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784260 | 1.00 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL8846420 | 1.00 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL7779691 | 1.00 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL8846588 | 1.00 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL8846372 | 0.86 | ENPP2 (0.44) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL30210402 | 0.85 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL7979145 | 0.85 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL7786705 | 0.83 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL7786720 | 0.83 | ENPP2 (0.43) | ENPP2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL6137115 | 0.83 | ENPP2 (0.40) | ENPP2CYP11B1CYP11B2FLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5652258-A | HISTAMINE ANTAGONISTS | GLIATECH, INC. (US) | 1997-07-29 | — | — | US | disclosed |