Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62691 | 0.84 | HTT (0.64) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL62692 | 0.84 | HTT (0.64) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL19289840 | 0.84 | HTT (0.64) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL7786849 | 0.82 | ALDH1A1 (0.48) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL1327511 | 0.81 | HTT (0.56) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL14930299 | 0.81 | HTT (0.56) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL1327514 | 0.81 | HTT (0.56) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL8517647 | 0.80 | HTT (0.56) | HTTALDH1A1KDM4EMAOAMAOB | |
| SCHEMBL7780082 | 0.80 | ALDH1A1 (0.54) | HTTALDH1A1KDM4ELMNAMAOA | |
| SCHEMBL18995758 | 0.79 | ALDH1A1 (0.60) | HTTALDH1A1KDM4ELMNAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140852-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARAMACEUTICAL USE | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035882-A1 | 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2000-06-22 | — | — | WO | disclosed |