Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 12/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800356 | 0.92 | DHODH (0.47) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL7780231 | 0.90 | MEN1 (0.46) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL6035677 | 0.85 | MAP2K1 (0.55) | MEN1KMT2AGFERSMN1; SMN2TDP1 | |
| SCHEMBL7851947 | 0.83 | MEN1 (0.59) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL5676620 | 0.81 | MEN1 (0.75) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL5872850 | 0.77 | MAP2K1 (0.56) | MEN1KMT2AGFERSMN1; SMN2TDP1 | |
| SCHEMBL4853895 | 0.76 | MEN1 (0.62) | MEN1KMT2ATDP1IDO1MAP2K2 | |
| SCHEMBL5872825 | 0.76 | HSP90AA1 (0.43) | MEN1KMT2AMAPTAKR1C3AKR1C2 | |
| SCHEMBL27563236 | 0.74 | IDO1 (0.53) | MEN1KMT2AAKR1C3AKR1C2GFER | |
| SCHEMBL7851949 | 0.74 | AKR1C3 (0.47) | MEN1KMT2ALMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |