Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780227 | 0.90 | MEN1 (0.52) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL7851949 | 0.83 | AKR1C3 (0.47) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL7800356 | 0.82 | DHODH (0.47) | MEN1KMT2ATDP1LMNAPOLB | |
| SCHEMBL6035677 | 0.75 | MAP2K1 (0.55) | MEN1KMT2ATDP1GFERSMN1; SMN2 | |
| SCHEMBL7851947 | 0.74 | MEN1 (0.59) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL5676620 | 0.71 | MEN1 (0.75) | MEN1KMT2ALMNAPOLBMAPT | |
| SCHEMBL4853895 | 0.71 | MEN1 (0.62) | MEN1KMT2ATDP1MAP2K2MAP2K1 | |
| SCHEMBL14594275 | 0.71 | MEN1 (0.62) | MEN1KMT2ATDP1MAP2K2MAP2K1 | |
| SCHEMBL4851861 | 0.69 | MEN1 (0.60) | MEN1KMT2ATDP1GFERSMN1; SMN2 | |
| SCHEMBL6138222 | 0.69 | MAP2K1 (0.60) | MEN1KMT2ATDP1MAP2K2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |