Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 12/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.46 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608035 | 0.88 | MEN1 (0.58) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5396199 | 0.88 | MAP2K1 (0.53) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL6227659 | 0.87 | MEN1 (0.58) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL6228743 | 0.87 | MAP2K1 (0.53) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5388138 | 0.79 | MAP2K1 (0.60) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5403672 | 0.79 | MEN1 (0.66) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5607777 | 0.79 | MEN1 (0.55) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL27471836 | 0.78 | MAP2K1 (0.41) | MEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL27484395 | 0.78 | MEN1 (0.53) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL6230066 | 0.74 | MAP2K1 (0.60) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |