Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CTSV | O60911 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7789000 | 0.88 | HTT (0.54) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL11850324 | 0.86 | MAPK1 (0.70) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL3764481 | 0.86 | MAPK1 (0.70) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL7785258 | 0.85 | MAPT (0.54) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL10727439 | 0.85 | MAPK1 (0.81) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL7787599 | 0.85 | MAPK1 (0.68) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL31406944 | 0.84 | HTT (0.55) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL9182030 | 0.83 | MAPT (0.61) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL6846139 | 0.82 | MAPK1 (1.00) | NPSR1HTTMAPK1GAAMAPT | |
| SCHEMBL4689851 | 0.82 | MAPK1 (0.67) | NPSR1HTTMAPK1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |