Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182030 | 0.90 | MAPT (0.61) | MAPTHTTNPSR1KMT2AMEN1 | |
| SCHEMBL7780381 | 0.85 | NPSR1 (0.70) | MAPTHTTNPSR1KMT2AMEN1 | |
| SCHEMBL7789143 | 0.84 | MAPT (0.64) | MAPTHTTKMT2AMEN1AHR | |
| SCHEMBL31406950 | 0.83 | RAB9A (0.59) | MAPTHTTKMT2AMEN1GAA | |
| SCHEMBL7785006 | 0.82 | NPC1 (0.59) | MAPTHTTNPSR1KMT2AMEN1 | |
| SCHEMBL7789011 | 0.80 | SMN1; SMN2 (0.73) | MAPTHTTKMT2AMEN1GAA | |
| SCHEMBL7789000 | 0.79 | HTT (0.54) | MAPTHTTNPSR1KMT2AMEN1 | |
| SCHEMBL10419633 | 0.77 | ALDH1A1 (0.64) | MAPTHTTNPSR1KMT2AMEN1 | |
| SCHEMBL28590005 | 0.77 | MEN1 (0.70) | MAPTHTTKMT2AMEN1GAA | |
| SCHEMBL3884099 | 0.76 | TDP1 (0.58) | MAPTHTTKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |