Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7801302 | 0.99 | S1PR3 (0.38) | S1PR3MAPKAPK2CXCR2TEAD4MAPK14 | |
| SCHEMBL7787572 | 0.94 | MAPKAPK2 (0.41) | S1PR3MAPKAPK2CXCR2TEAD4MAPK14 | |
| SCHEMBL7805555 | 0.94 | MAPKAPK2 (0.38) | MAPKAPK2CXCR2TEAD4MAPK14THRA | |
| SCHEMBL7785267 | 0.94 | MAPKAPK2 (0.38) | MAPKAPK2CXCR2TEAD4MAPK14THRA | |
| Hydrochloric Acid SCHEMBL7795475 | 0.93 | MAPKAPK2 (0.38) | MAPKAPK2CXCR2TEAD4MAPK14THRA | |
| SCHEMBL7780525 | 0.93 | MAPKAPK2 (0.42) | MAPKAPK2CXCR2TEAD4MAPK14 | |
| Hydrochloric Acid SCHEMBL7784929 | 0.92 | MAPKAPK2 (0.42) | MAPKAPK2CXCR2TEAD4MAPK14 | |
| SCHEMBL7780626 | 0.91 | S1PR3 (0.38) | S1PR3MAPKAPK2CXCR2MAPK14THRA | |
| Hydrochloric Acid SCHEMBL7795463 | 0.90 | S1PR3 (0.38) | S1PR3MAPKAPK2CXCR2MAPK14THRA | |
| Hydrochloric Acid SCHEMBL7801920 | 0.90 | S1PR3 (0.38) | S1PR3MAPKAPK2CXCR2MAPK14THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |