Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780573 | 0.94 | S1PR3 (0.39) | MAPKAPK2S1PR3RAPGEF4TEAD4CXCR2 | |
| SCHEMBL7785305 | 0.94 | MAPKAPK2 (0.42) | MAPKAPK2RAPGEF4TEAD4MTORCXCR2 | |
| SCHEMBL7785614 | 0.94 | MAPKAPK2 (0.42) | MAPKAPK2RAPGEF4TEAD4MTORCXCR2 | |
| Hydrochloric Acid SCHEMBL7801302 | 0.93 | S1PR3 (0.38) | MAPKAPK2S1PR3RAPGEF4TEAD4CXCR2 | |
| Hydrochloric Acid SCHEMBL7780386 | 0.93 | MAPKAPK2 (0.41) | MAPKAPK2RAPGEF4TEAD4MTORCXCR2 | |
| SCHEMBL7787894 | 0.93 | MAPKAPK2 (0.47) | MAPKAPK2TEAD4MTORCXCR2CXCR1 | |
| Hydrochloric Acid SCHEMBL7785463 | 0.92 | MAPKAPK2 (0.46) | MAPKAPK2TEAD4MTORCXCR2CXCR1 | |
| SCHEMBL7785139 | 0.91 | S1PR3 (0.40) | MAPKAPK2S1PR3RAPGEF4TEAD4CXCR2 | |
| SCHEMBL7787803 | 0.91 | MAPKAPK2 (0.40) | MAPKAPK2S1PR3RAPGEF4TEAD4MTOR | |
| Hydrochloric Acid SCHEMBL7780307 | 0.90 | S1PR3 (0.39) | MAPKAPK2S1PR3RAPGEF4TEAD4CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |