Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 2/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076135 | 0.88 | PDE5A (0.54) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5795456 | 0.86 | CA12 (0.59) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7449440 | 0.82 | PDE5A (0.56) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7365582 | 0.78 | PDE5A (0.46) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL31202702 | 0.77 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL1190 | 0.77 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6249945 | 0.77 | PDE5A (0.48) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6634460 | 0.75 | PDE5A (0.55) | PDE5A | |
| SCHEMBL6716971 | 0.75 | PDE5A (0.76) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL18069563 | 0.74 | PDE5A (0.60) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140044-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | Novartis AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037061-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | NOVARTIS AG (CH) | 2000-06-29 | — | — | WO | disclosed |