Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 6/20 | 0.51 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595129 | 0.87 | PDE5A (0.52) | KDM4EALDH1A1PKMTAAR1PDE5A | |
| Hydrochloric Acid SCHEMBL7278529 | 0.86 | PDE5A (0.53) | KDM4EALDH1A1PKMTAAR1PDE5A | |
| SCHEMBL4859938 | 0.81 | RAD52 (0.69) | RAD52ACHEKMT2ALMNAKDM4E | |
| SCHEMBL3976866 | 0.74 | APP (0.68) | RAD52ACHEKMT2ALMNAKDM4E | |
| SCHEMBL4864671 | 0.72 | APP (0.70) | RAD52ACHEKMT2ALMNAKDM4E | |
| SCHEMBL12175837 | 0.71 | RAD52 (1.00) | RAD52ACHEKMT2ALMNAKDM4E | |
| SCHEMBL7431532 | 0.71 | KMT2A (0.77) | RAD52KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL9243 | 0.70 | TAAR1 (1.00) | KMT2ALMNAKDM4EALDH1A1MAPT | |
| SCHEMBL7435745 | 0.70 | CYP1A2 (0.64) | RAD52ACHEKMT2ALMNAKDM4E | |
| SCHEMBL4861406 | 0.70 | APP (0.71) | RAD52ACHEKMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140044-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | Novartis AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037061-A2 | cGMP PDE 5 INHIBITORS FOR INHALATION IN THE TREATMENT OF SEXUAL DYSFUNCTION | NOVARTIS AG (CH) | 2000-06-29 | — | — | WO | disclosed |