Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 13/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 9/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.52 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.52 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL11269603 | 1.00 | GRIK1 (0.54) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL7158842 | 0.91 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL135731 | 0.90 | GRIK1 (0.57) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL7781258 | 0.90 | GRIK1 (0.57) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL7781260 | 0.90 | GRIK1 (0.57) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL28302585 | 0.90 | SLC7A5 (0.52) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL27469897 | 0.90 | SLC7A5 (0.52) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL8383423 | 0.90 | SLC7A5 (0.56) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL7204819 | 0.90 | SLC7A5 (0.56) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 | |
| Aspartic Acid SCHEMBL28054217 | 0.90 | SLC7A5 (0.56) | GRIK1GRIK2SLC1A2SLC1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106893644-B | A kind of Wax removal water and its application, preparation, paraffin removal method | 比亚迪股份有限公司 | 2019-08-13 | — | — | CN | claimed |
| CN-106893644-B | A kind of Wax removal water and its application, preparation, paraffin removal method | 比亚迪股份有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-108165376-A | A kind of detergent | 山东泰和水处理科技股份有限公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-107184555-B | A kind of Procaterol Hydrochloride granule | 黑龙江龙德药业有限公司 | 2018-06-01 | — | — | CN | disclosed |
| US-9957417-B2 | Fast cure aspartate polysiloxane hybrid coating | COVESTRO LLC (US) | 2018-05-01 | — | — | US | disclosed |
| CN-107184555-A | A kind of Procaterol Hydrochloride granule and preparation method thereof | 黑龙江龙德药业有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-106893644-A | A kind of Wax removal water and its application, preparation, paraffin removal method | 比亚迪股份有限公司 | 2017-06-27 | — | — | CN | disclosed |
| US-20150291846-A1 | Fast Cure Aspartate Polysiloxane Hybrid Coating | COVESTRO LLC | 2015-10-15 | — | — | US | disclosed |
| US-9085712-B2 | Fast cure aspartate polysiloxane hybrid coating | BAYER MATERIALSCIENCE LLC (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140272424-A1 | FAST CURE ASPARTATE POLYSILOXANE HYBRID COATING | COVESTRO LLC | 2014-09-18 | — | — | US | disclosed |
| CN-101253210-B | Prepolymers containing alkoxysilane groups and specific allophanate and/or biuret groups, method for the production and use thereof | BAYER MATERIALSCIENCE AG | 2011-09-07 | — | — | CN | disclosed |
| CN-101687058-A | Method for producing polyurethane foams for wound treatment | BAYER MATERIALSCIENCE AG | 2010-03-31 | — | — | CN | disclosed |
| CN-101253210-A | Prepolymers containing alkoxysilane groups and specific allophanate and/or biuret groups, method for the production and use thereof | BAYER MATERIALSCIENCE AG (DE) | 2008-08-27 | — | — | CN | disclosed |
| EP-1135398-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | Monsanto Technology LLC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6218563-B1 | Cyanophosphonamides and method for preparation | MONSANTO COMPANY | 2001-04-17 | — | — | US | disclosed |
| WO-2000032611-A1 | CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION | MONSANTO TECHNOLOGY LLC (US) | 2000-06-08 | — | — | WO | disclosed |