SCHEMBL7783072

SCHEMBL7783072

COc1ccc(-c2ccc(Br)cc2)cc1F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 1/20 0.57
PDGFRB P09619 1/20 0.51
PDGFRA P16234 1/20 0.51
ERN1 O75460 1/20 0.50
TDP2 O95551 1/20 0.50
MEN1 O00255 2/20 0.49
ALDH1A1 P00352 2/20 0.49
RAB9A P51151 2/20 0.49
KMT2A Q03164 2/20 0.49
NPC1 O15118 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
PTGS2 P35354 5/20 0.47
PTGS1 P23219 2/20 0.46
LMNA P02545 1/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
NAAA Q02083 1/20 0.46
MAPT P10636 1/20 0.46
FFAR1 O14842 1/20 0.46
TUBB1 Q9H4B7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9464193 0.89 CYP17A1 (0.61) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL15605813 0.86 CYP17A1 (0.58) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL29677789 0.85 HTT (0.50) ALDH1A1RAB9ANPC1SMN1; SMN2LMNA
SCHEMBL282059 0.85 HTT (0.50) ALDH1A1RAB9ANPC1SMN1; SMN2LMNA
SCHEMBL8481713 0.84 CYP17A1 (0.57) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL19722074 0.84 CYP17A1 (0.57) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL10093049 0.84 CYP17A1 (0.57) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL20699887 0.83 PDE4A (0.53) PDGFRBPDGFRAERN1ALDH1A1MAPK1
SCHEMBL8656197 0.83 CYP17A1 (0.56) CYP17A1PDGFRBPDGFRAERN1TDP2
SCHEMBL7108662 0.83 HTT (0.48) ALDH1A1RAB9ANPC1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed