SCHEMBL7783307

SCHEMBL7783307

COc1cc(OCCO)c(Cl)cc1N.COc1cc(OCCO)c(N)cc1Cl

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.66
NPC1 O15118 3/20 0.47
ALDH1A1 P00352 4/20 0.42
L3MBTL1 Q9Y468 4/20 0.42
MAPT P10636 3/20 0.42
HPGD P15428 3/20 0.42
POLB P06746 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
MEN1 O00255 1/20 0.42
USP2 O75604 1/20 0.42
ALOX12 P18054 1/20 0.42
MAPK1 P28482 1/20 0.42
KMT2A Q03164 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
TAAR1 Q96RJ0 1/20 0.38
TUBB1 Q9H4B7 1/20 0.38
DYRK1A Q13627 1/20 0.37
CYP3A4 P08684 2/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6815691 0.97 GAA (0.65) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL6815051 0.97 GAA (0.65) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL8034582 0.87 GAA (0.47) GAAALDH1A1L3MBTL1MAPTPOLB
Hydrochloric Acid SCHEMBL10891581 0.85 GAA (0.46) GAAALDH1A1L3MBTL1MAPTPOLB
SCHEMBL92047 0.81 GAA (1.00) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL6819732 0.81 GAA (0.65) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL2794920 0.81 GAA (0.65) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL11707698 0.80 GAA (0.46) GAANPC1ALDH1A1
SCHEMBL11794328 0.79 CD44 (0.39) GAANPC1ALDH1A1L3MBTL1MAPT
SCHEMBL6814560 0.78 GAA (0.71) GAANPC1ALDH1A1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144397-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144397-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034258-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed