SCHEMBL7783490

SCHEMBL7783490

CN(C)CCCOc1ccc(N)cc1Cl.CN(C)CCOc1ccc(N)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.51
ALDH1A1 P00352 2/20 0.51
LMNA P02545 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
MAPK1 P28482 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2D6 P10635 2/20 0.47
CYP2C19 P33261 2/20 0.47
HPGD P15428 2/20 0.47
MAOA P21397 2/20 0.47
NPC1 O15118 1/20 0.47
CYP3A4 P08684 1/20 0.47
TSHR P16473 1/20 0.47
MAOB P27338 1/20 0.47
THPO P40225 1/20 0.47
RAB9A P51151 1/20 0.47
HIF1A Q16665 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MAPT P10636 2/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6816572 0.97 KDM4E (0.53) KDM4EALDH1A1LMNATDP1MAPK1
SCHEMBL1641708 0.95 KDM4E (0.50) KDM4EALDH1A1LMNATDP1MAPK1
Hydrochloric Acid SCHEMBL1641323 0.94 KDM4E (0.49) KDM4EALDH1A1LMNATDP1MAPK1
Hydrochloric Acid SCHEMBL1640342 0.94 KDM4E (0.49) KDM4EALDH1A1LMNATDP1MAPK1
SCHEMBL4632811 0.83 UTS2R (0.49) KDM4EALDH1A1MAPK1MAPTGAA
SCHEMBL4008967 0.82 KDM4E (0.54) KDM4EALDH1A1TDP1MAPK1CYP1A2
SCHEMBL10494874 0.81 KDM4E (0.62) KDM4EALDH1A1CYP1A2CYP2D6CYP2C19
SCHEMBL7783491 0.81 KDR (0.52) KDM4EALDH1A1LMNATDP1MAPK1
SCHEMBL3857536 0.80 MAOA (0.57) KDM4EALDH1A1TDP1CYP1A2CYP2D6
SCHEMBL21558822 0.80 CYP2C19 (0.67) KDM4EALDH1A1LMNATDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144397-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144397-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
WO-2000034258-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed